منابع مشابه
Hemoglobin Polymorphism and Susceptibility to Plasmodium Infection in Mice.
TUDIES in man of the relationship between hemoglobinopathies and infections with Plasmodium fakiparum have focused attention on the possible role of infectious diseases in natural selection and in the maintenance of polymorphic systems (ALLISON 1961 ) . However, data obtained from human populations are mostly of circumstantial nature. Experimental work in animals attempting to analyze the effec...
متن کاملHemoglobin polymorphism in white-tailed deer: subunit basis.
By H’ mit si KITCHEN, FRANK W . PUTNAM AND \V. JAPE TAYLOR I HE SICKLING OF ERYTHROCYTES under in vitro laboratory conditions has been demonstrated in most species of deer. This remarkable distortion of the erythrocytes from the biconcave disc shape to such bizarre forms as holly leaf, crescent and oat shapes in several species of deer was first described by Gulliver in 1840. Seventy years late...
متن کاملAssociation of Xmn I Polymorphism and Hemoglobin E Haplotypes on Postnatal Gamma Globin Gene Expression in Homozygous Hemoglobin E
Background and Objectives. To explore the role of cis-regulatory sequences within the β globin gene cluster at chromosome 11 on human γ globin gene expression related to Hb E allele, we analyze baseline hematological data and Hb F values together with β globin haplotypes in homozygous Hb E. Patients and Methods. 80 individuals with molecularly confirmed homozygous Hb E were analyzed for the β g...
متن کاملRole of XmnIgG Polymorphism in Hydroxyurea Treatment and Fetal Hemoglobin Level at Isfahanian Intermediate β-Thalassemia Patients
Background: &beta-thalassemia is the most common monogenic disorder in human. The (CT) polymorphism at -158 upstream region of the &gammaG-globin gene and pharmacological factors such as hydroxyurea have been reported to influence &gamma-globin gene expression and the severity of clinical symptoms of &beta-thalassemia. Methods: In the present study, 51 &beta-thalassemia intermediate patients w...
متن کاملVariation of Fetal Hemoglobin and F-Cell Number With the LCR-HS2 Polymorphism in Nonanemic Individuals
To the Editor: remains const t and seems to be under genetic control.' Available data suggest that at least two types of genetic determinants might In normal adults. synthesis of fetal hemoglobin (HbF) persists at be involved in the level of HbF expression: one linked to the pa very low level ( < I % ) and is restricted to a subpopulation of globin gene cluste?.' and the other(s) unlinke...
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ژورنال
عنوان ژورنال: Science
سال: 1971
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.171.3972.706-a